So, I think to deal with chemical and biochemical processes via Asgardia, we need to really nail epigenetics. For those that do not know, epigenetics is the study of gene modification versus genetic replacement. Biochemically, we would need to do something to deal with microgravity. Microgravity is the biggest problem most people do not think of. There are many posts here on the effects of space on the human body (i.e. heart, eyes, bone density). At some point, I am sure that artificial gravity will be a thing. The spinning wheel that is seen in all sorts of sci fi settings is probably the easiest to reproduce, but the cost to put something like that in space is astronomical. That being said, I think we need to modify the genome to deal first and foremost with the body's program to move fluids. Since we as humans are just bags of fluid, and most of the ailments found in astronauts are fluid displacement issues (urination, heart weakening, and eye weakening), some sort of switch could be toggled in the sodium/potassium channels possibly, or calcium ionization so as to flex muscles involutarily to make sure everything moves (like bowel parastalsis).

Im very interested in senescence and relevant biochemistry/genetics myself being a Biotechnologist. Im very excited about the research potential that comes with the Asgardian dream so Im hoping I can contribute in those areas, I want to make living in space a cakewalk for our future generations. Peace and love